How Much Does a HPLC system Cost? The typical price of a new HPLC system costs in the range of $20,000 - $150,000, whereas a used HPLC system ranges in price from $2,500 - $75,000 The typical price of a new HPLC system costs in the range of $20,000 - $150,000, whereas a used HPLC system ranges in price from $2,500 - $75,000